T-helper 1 cell differentiation

Across TCGA cell cohorts, RNA activity of the T-helper 1 cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ELAC1, SMIM3, and LIMA1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ELAC1 grouped by T-helper 1 cell differentiation-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ELAC1 →	+1.120	+0.327	<.001	.004	3	4
BREAST	SMIM3 →	+1.026	+0.138	.001	<.001	3	4
BREAST	LIMA1 →	+1.653	+0.160	.002	<.001	3	4
LUNG_SCLC	TWSG1 →	+1.535	+0.227	<.001	.001	3	4
PANCREAS	BEAN1 →	+0.838	+0.345	.006	.003	3	4
BLOOD_Myeloma	LXN →	-2.182	-0.278	.006	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ELAC1 by T-helper 1 cell differentiation activity — SOFT_TISSUE

Explore this box plot interactively →