T-helper 1 cell differentiation

Across TCGA cell cohorts, RNA activity of the T-helper 1 cell differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PSMB6, PSMB5, and SLC7A9, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PSMB6 grouped by T-helper 1 cell differentiation-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PSMB6 →	-0.531	-0.096	.002	.004	3	6
URINARY_TRACT	PSMB5 →	-0.761	-0.175	<.001	<.001	3	5
OVARY	SLC7A9 →	-0.191	-0.140	<.001	<.001	3	4
LUNG_NSCLC_LUSC	DLX6 →	+0.321	+0.147	.003	<.001	3	4
LUNG_NSCLC_LUAD	IGF1R →	-0.153	-0.076	.005	.006	2	5
SKIN	PSMA6 →	+0.221	+0.075	.009	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PSMB6 by T-helper 1 cell differentiation activity — CNS

Explore this box plot interactively →