T-helper 1 cell differentiation

Across TCGA cell cohorts, RNA activity of the T-helper 1 cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GRK2, CSNK1G2, and ATP6V1A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, T-helper 1 cell differentiation activity versus GRK2 in LIVER (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	GRK2 →	+1.487	+0.332	.004	.003	3	6
OVARY	CSNK1G2 →	+0.614	+0.399	<.001	<.001	3	6
LIVER	ATP6V1A →	+1.150	+0.369	.002	.001	3	5
UPPER_AERODIGESTIVE_TRACT	SCO1 →	+0.825	+0.440	<.001	.002	3	5
OVARY	GINS3 →	+0.912	+0.388	.006	.002	3	5
SOFT_TISSUE	DLG1 →	-1.314	-0.332	.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045063 vs GRK2 — LIVER

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