Thymic T cell selection

Across TCGA patient cohorts, RNA activity of the Thymic T cell selection pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RCSD1, RCSD1_S179, and RHOG, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Thymic T cell selection activity versus RCSD1 in LSCC (Pearson r = 0.63).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RCSD1 →	+0.677	+0.134	<.001	<.001	3	10
LSCC	RCSD1_S179 →	+0.932	+0.150	<.001	<.001	3	10
OV	RHOG →	+0.367	+0.092	<.001	<.001	3	10
LSCC	SEPTIN1 →	+1.007	+0.164	<.001	<.001	3	10
LSCC	SIPA1_S839 →	+0.625	+0.104	<.001	<.001	3	10
UCEC	WAS →	+0.667	+0.103	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045061 vs RCSD1 — LSCC

Explore this scatter interactively →