Thymic T cell selection

Across TCGA patient cohorts, RNA activity of the Thymic T cell selection pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SELL, CSF2RB, and RASAL3, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Thymic T cell selection activity versus SELL in BRCA (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SELL →	+1.572	+0.991	<.001	<.001	3	10
BRCA	CSF2RB →	+0.886	+0.588	<.001	<.001	3	9
BRCA	RASAL3 →	+0.719	+0.715	<.001	<.001	3	9
LSCC	CYTIP →	+0.892	+0.810	<.001	<.001	3	9
BRCA	LAX1 →	+1.433	+1.016	<.001	<.001	3	9
HNSC	LY9 →	+0.643	+0.512	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045061 vs SELL — BRCA

Explore this scatter interactively →