Thymic T cell selection

Across TCGA cell cohorts, RNA activity of the Thymic T cell selection pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IDUA, WWP1, and ITGA3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IDUA grouped by Thymic T cell selection-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	IDUA →	+1.255	+0.190	.002	.002	3	5
LIVER	WWP1 →	-0.821	-0.422	.004	<.001	3	4
BREAST	ITGA3 →	+1.859	+0.143	<.001	.001	3	4
UPPER_AERODIGESTIVE_TRACT	MYO1E →	+1.488	+0.360	.007	.002	3	4
KIDNEY	NUDT5 →	-0.727	-0.329	.009	<.001	3	4
SOFT_TISSUE	ACER2 →	+0.722	+0.217	<.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IDUA by Thymic T cell selection activity — CNS

Explore this box plot interactively →