Thymic T cell selection

Across TCGA cell cohorts, RNA activity of the Thymic T cell selection pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TTF2, SNRNP27, and TRAF3IP1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Thymic T cell selection activity versus TTF2 in PANCREAS (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	TTF2 →	+0.573	+0.283	.002	.004	2	7
LUNG_NSCLC_LUSC	SNRNP27 →	+1.077	+0.587	.009	.007	3	6
PANCREAS	TRAF3IP1 →	+0.851	+0.346	<.001	.002	3	6
SKIN	DCK →	+0.501	+0.236	<.001	.002	3	6
UPPER_AERODIGESTIVE_TRACT	DBR1 →	+0.709	+0.363	.005	.007	2	6
PANCREAS	NFIC →	+1.275	+0.311	.001	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045061 vs TTF2 — PANCREAS

Explore this scatter interactively →