Positive thymic T cell selection

Across TCGA patient cohorts, RNA activity of the Positive thymic T cell selection pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are JAML, GRAP2, and PIK3CG, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive thymic T cell selection activity versus JAML in UCEC (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JAML →	+0.919	+0.352	<.001	<.001	3	8
BRCA	GRAP2 →	+0.882	+0.843	<.001	<.001	3	7
UCEC	PIK3CG →	+0.680	+0.487	<.001	<.001	3	7
UCEC	GIMAP2 →	+0.822	+0.369	.002	.001	3	7
BRCA	CCR2 →	+0.965	+0.516	<.001	<.001	3	7
HNSC	FAM78A →	+0.536	+0.159	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045059 vs JAML — UCEC

Explore this scatter interactively →