Positive thymic T cell selection

Across TCGA cell cohorts, RNA activity of the Positive thymic T cell selection pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF583, SMURF1, and PRRT1, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive thymic T cell selection activity versus ZNF583 in BLOOD_Leukemia (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ZNF583 →	+0.674	+0.135	<.001	.001	3	1
BLOOD_Leukemia	SMURF1 →	-0.500	-0.176	.008	.002	3	1
BLOOD_Leukemia	PRRT1 →	-0.790	-0.127	.003	.003	3	1
BLOOD_Leukemia	PPM1N →	-1.095	-0.127	<.001	.003	3	1
BLOOD_Leukemia	CCNL2 →	-1.022	-0.178	.004	.003	3	1
BLOOD_Leukemia	TMEM250 →	+1.073	+0.190	.006	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045059 vs ZNF583 — BLOOD_Leukemia

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