Positive thymic T cell selection

Across TCGA cell cohorts, RNA activity of the Positive thymic T cell selection pathway is significantly associated with the drug response of multiple features, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are (5Z)-7-Oxozeaenol, BAY-MPS1, and Dyrk1b_0191, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, (5Z)-7-Oxozeaenol grouped by Positive thymic T cell selection-low versus -high activity in BLOOD_Leukemia.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	(5Z)-7-Oxozeaenol →	+0.521	+0.165	.011	.041	3	1
BLOOD_Leukemia	BAY-MPS1 →	+1.181	+0.141	.003	.019	3	1
BLOOD_Leukemia	Dyrk1b_0191 →	+0.419	+0.136	.034	.009	3	1
BLOOD_Leukemia	N25720-51-A1 →	-0.481	-0.194	<.001	.021	3	1
BLOOD_Leukemia	Ispinesib Mesylate →	-0.305	-0.163	.012	.023	3	1
BLOOD_Leukemia	QL-XII-47 →	-0.300	-0.156	.035	.012	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

(5Z)-7-Oxozeaenol by Positive thymic T cell selection activity — BLOOD_Leukemia

Explore this box plot interactively →