T cell selection

Across TCGA patient cohorts, RNA activity of the T cell selection pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RCSD1, RHOG, and SAMSN1_S107, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, T cell selection activity versus RCSD1 in HNSC (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RCSD1 →	+0.674	+0.098	<.001	<.001	3	10
OV	RHOG →	+0.328	+0.037	<.001	<.001	3	10
OV	SAMSN1_S107 →	+0.910	+0.040	<.001	<.001	3	10
BRCA	SAMSN1_S23 →	+0.937	+0.054	<.001	<.001	3	10
OV	SKAP2 →	+0.668	+0.049	<.001	<.001	3	10
PDAC	SLC9A9 →	+0.429	+0.052	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045058 vs RCSD1 — HNSC

Explore this scatter interactively →