T cell selection

Across TCGA patient cohorts, RNA activity of the T cell selection pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RASAL3, CD4, and CRTAM, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, T cell selection activity versus RASAL3 in BRCA (Pearson r = 0.05).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RASAL3 →	+1.126	+0.876	<.001	<.001	3	9
GBM	CD4 →	+0.654	+0.223	<.001	<.001	3	9
HNSC	CRTAM →	+0.669	+0.534	<.001	<.001	3	9
HNSC	ITK →	+1.064	+0.629	<.001	<.001	3	9
HNSC	ARHGAP9 →	+0.864	+0.589	<.001	<.001	3	9
BRCA	FAM78A →	+0.749	+0.706	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045058 vs RASAL3 — BRCA

Explore this scatter interactively →