T cell selection

Across TCGA cell cohorts, RNA activity of the T cell selection pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DFFB, CLCC1, and MAIP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DFFB grouped by T cell selection-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	DFFB →	-0.487	-0.155	.008	.003	3	4
LUNG_NSCLC_LUSC	CLCC1 →	-1.050	-0.168	.002	<.001	3	4
SOFT_TISSUE	MAIP1 →	+0.722	+0.456	<.001	.009	3	3
SOFT_TISSUE	ZNF587B →	+0.736	+0.374	<.001	.003	3	3
BREAST	SFXN3 →	+0.909	+0.116	.004	.007	3	3
BREAST	NXNL2 →	+0.972	+0.263	.006	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DFFB by T cell selection activity — BREAST

Explore this box plot interactively →