T cell selection

Across TCGA cell cohorts, RNA activity of the T cell selection pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DBR1, DUS3L, and PCBP1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, T cell selection activity versus DBR1 in LUNG_SCLC (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	DBR1 →	+0.728	+0.249	<.001	.005	3	7
OVARY	DUS3L →	+0.799	+0.356	.001	.002	3	6
OVARY	PCBP1 →	+0.616	+0.431	.005	.003	2	7
BLOOD_Myeloma	RELB →	-1.730	-0.201	<.001	.005	3	5
BREAST	METTL21A →	+0.927	+0.266	<.001	.004	3	5
LARGE_INTESTINE	SDHAF3 →	+1.242	+0.333	.006	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045058 vs DBR1 — LUNG_SCLC

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