Regulated exocytosis

Across TCGA patient cohorts, RNA activity of the Regulated exocytosis pathway is significantly associated with the RNA expression of multiple genes, with the SKCM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CSF2RB, FGL2, and PLCB2, each associated with the pathway in up to 33 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulated exocytosis activity versus CSF2RB in SKCM (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CSF2RB →	+1.613	+0.026	<.001	<.001	3	33
LAML	FGL2 →	+2.105	+0.040	<.001	<.001	3	33
DLBC	PLCB2 →	+1.467	+0.041	<.001	.002	3	33
BLCA	ITGAX →	+1.309	+0.021	<.001	<.001	3	33
LAML	FGD2 →	+1.602	+0.029	<.001	<.001	3	33
SKCM	CCR5 →	+1.748	+0.024	<.001	<.001	3	33

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045055 vs CSF2RB — SKCM

Explore this scatter interactively →