Regulated exocytosis

Across TCGA patient cohorts, RNA activity of the Regulated exocytosis pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ARHGAP4, RCSD1_S351, and WAS, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulated exocytosis activity versus ARHGAP4 in UCEC (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ARHGAP4 →	+0.482	+0.053	<.001	<.001	3	10
UCEC	RCSD1_S351 →	+0.643	+0.043	<.001	<.001	3	9
UCEC	WAS →	+0.446	+0.031	<.001	<.001	3	9
OV	BTK →	+0.658	+0.031	<.001	<.001	3	9
OV	CORO1A →	+0.752	+0.024	<.001	.003	3	9
HNSC	DOCK10 →	+0.403	+0.043	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045055 vs ARHGAP4 — UCEC

Explore this scatter interactively →