Regulated exocytosis

Across TCGA patient cohorts, RNA activity of the Regulated exocytosis pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CACNA1I, HDAC8, and DSPP, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulated exocytosis activity versus CACNA1I in OV (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CACNA1I →	+0.200	+0.181	.006	.005	3	2
OV	HDAC8 →	+0.348	+0.181	<.001	.001	3	2
OV	DSPP →	+0.066	+0.160	.003	<.001	3	2
OV	GABRG3 →	+0.582	+0.129	.003	.008	3	2
OV	ZNF275 →	+0.745	+0.148	.001	.006	3	2
BRCA	SHC3 →	+0.807	+0.436	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045055 vs CACNA1I — OV

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