Regulated exocytosis

Across TCGA cell cohorts, RNA activity of the Regulated exocytosis pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZC3H3, DNAAF5, and FN3K, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZC3H3 grouped by Regulated exocytosis-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	ZC3H3 →	-0.669	-1.702	.002	<.001	3	3
URINARY_TRACT	DNAAF5 →	-1.107	-1.760	.006	<.001	3	3
OVARY	FN3K →	+1.284	+0.825	.006	.005	3	3
PANCREAS	CIT →	-0.721	-1.003	.008	.001	3	3
LUNG_NSCLC_LUAD	GOSR2 →	-0.533	-1.005	<.001	<.001	3	3
LUNG_NSCLC_LUSC	RPS13 →	-0.751	-1.213	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZC3H3 by Regulated exocytosis activity — URINARY_TRACT

Explore this box plot interactively →