Regulated exocytosis

Across TCGA cell cohorts, RNA activity of the Regulated exocytosis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPRC5A, SBDS, and KLHL15, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulated exocytosis activity versus GPRC5A in LUNG_NSCLC_LUAD (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GPRC5A →	+1.552	+0.155	.003	.008	3	7
OESOPHAGUS	SBDS →	+0.933	+0.199	.005	.002	3	6
PANCREAS	KLHL15 →	-1.051	-0.279	.001	.001	3	6
LUNG_SCLC	CCDC138 →	-0.828	-0.233	.001	.002	3	6
BONE	MGLL →	+2.601	+0.290	.007	.003	3	6
STOMACH	CTSD →	+1.514	+0.326	.003	.002	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045055 vs GPRC5A — LUNG_NSCLC_LUAD

Explore this scatter interactively →