Constitutive secretory pathway

Across TCGA cell cohorts, RNA activity of the Constitutive secretory pathway pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZMYM3, SOGA1, and TUBA1A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZMYM3 grouped by Constitutive secretory pathway-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ZMYM3 →	+0.998	+0.594	.003	.008	3	3
STOMACH	SOGA1 →	+2.386	+0.581	.003	.005	3	3
STOMACH	TUBA1A →	+3.804	+0.612	.007	.003	3	3
STOMACH	PKIG →	+3.801	+0.621	<.001	.003	3	3
LUNG_NSCLC_LUSC	PDZD9 →	+0.085	+1.034	.003	.005	3	3
BONE	OPRL1 →	+1.656	+0.584	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZMYM3 by Constitutive secretory pathway activity — STOMACH

Explore this box plot interactively →