Constitutive secretory pathway

Across TCGA cell cohorts, RNA activity of the Constitutive secretory pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CUL4A, SLC16A8, and MYH9, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CUL4A grouped by Constitutive secretory pathway-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CUL4A →	+0.305	+0.319	.003	.002	3	2
BREAST	SLC16A8 →	-0.251	-0.327	.002	.001	3	1
BREAST	MYH9 →	+0.546	+0.411	<.001	.004	3	1
BREAST	HAGHL →	-0.295	-0.449	.004	.009	3	1
BREAST	PLA2G4C →	+0.194	+0.319	.009	.002	3	1
BREAST	SFXN3 →	-0.176	-0.410	.003	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CUL4A by Constitutive secretory pathway activity — BREAST

Explore this box plot interactively →