Protein insertion into ER membrane by stop-transfer membrane-anchor sequence

Across TCGA patient cohorts, RNA activity of the Protein insertion into ER membrane by stop-transfer membrane-anchor sequence pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WNK1_S1978, WNK1_S2230, and WNK1_S2264, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein insertion into ER membrane by stop-transfer membrane-anchor sequence activity versus WNK1_S1978 in PDAC (Pearson r = 0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	WNK1_S1978 →	+0.464	+0.605	<.001	<.001	3	4
PDAC	WNK1_S2230 →	+0.464	+0.605	<.001	<.001	3	4
PDAC	WNK1_S2264 →	+1.465	+0.882	<.001	<.001	3	4
HNSC	WNK1 →	+0.348	+0.351	<.001	<.001	3	3
OV	JUNB_T102 →	+1.216	+0.232	<.001	.001	3	3
BRCA	SLC2A1 →	+0.678	+0.167	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045050 vs WNK1_S1978 — PDAC

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