Protein insertion into ER membrane by stop-transfer membrane-anchor sequence

Across TCGA cell cohorts, RNA activity of the Protein insertion into ER membrane by stop-transfer membrane-anchor sequence pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EMC4, KIAA0586, and SEC31B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EMC4 grouped by Protein insertion into ER membrane by stop-transfer membrane-anchor sequence-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	EMC4 →	-0.239	-0.713	<.001	.004	3	4
LUNG_NSCLC_LUAD	KIAA0586 →	+0.096	+0.733	.007	.003	3	3
LUNG_NSCLC_LUAD	SEC31B →	+0.133	+0.778	<.001	.001	3	3
LUNG_SCLC	OCEL1 →	+0.164	+0.455	.002	.001	2	4
SKIN	FOXO1 →	+0.157	+1.065	.008	<.001	3	3
SKIN	EXD3 →	-0.147	-1.487	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EMC4 by Protein insertion into ER membrane by stop-transfer membrane-anchor sequence activity — LUNG_NSCLC_LUAD

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