Protein insertion into ER membrane by stop-transfer membrane-anchor sequence

Across TCGA cell cohorts, RNA activity of the Protein insertion into ER membrane by stop-transfer membrane-anchor sequence pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYLD, ZNF365, and TMPRSS4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein insertion into ER membrane by stop-transfer membrane-anchor sequence activity versus CYLD in KIDNEY (Pearson r = 0.82).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	CYLD →	+1.105	+1.478	<.001	<.001	3	3
LUNG_NSCLC_LUAD	ZNF365 →	+0.817	+0.707	<.001	.006	3	3
OVARY	TMPRSS4 →	+3.176	+0.258	.002	<.001	3	3
OVARY	TNFSF15 →	+0.818	+0.194	.002	.004	2	4
BREAST	SLC25A14 →	+0.962	+1.243	<.001	<.001	3	3
BREAST	MYOF →	+1.824	+0.778	.004	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045050 vs CYLD — KIDNEY

Explore this scatter interactively →