Protein insertion into ER membrane by stop-transfer membrane-anchor sequence

Across TCGA cell cohorts, RNA activity of the Protein insertion into ER membrane by stop-transfer membrane-anchor sequence pathway is significantly associated with the protein abundance of multiple proteins, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EMC7, EMC2, and EMC8, each associated with the pathway in up to 17 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein insertion into ER membrane by stop-transfer membrane-anchor sequence activity versus EMC7 in BLOOD_Lymphoma (Pearson r = 0.65).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	EMC7 →	+1.285	+1.238	<.001	<.001	3	16
BLOOD_Lymphoma	EMC2 →	+1.058	+1.335	<.001	<.001	2	17
BREAST	EMC8 →	+0.741	+0.881	<.001	<.001	3	16
BLOOD_Lymphoma	EMC1 →	+1.088	+1.295	<.001	<.001	2	15
STOMACH	MMGT1 →	+1.127	+0.941	.004	.006	2	13
SOFT_TISSUE	SSR4 →	+1.186	+1.158	.002	.008	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045050 vs EMC7 — BLOOD_Lymphoma

Explore this scatter interactively →