Protein insertion into ER membrane

Across TCGA patient cohorts, RNA activity of the Protein insertion into ER membrane pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TOM1L2, GORASP2_T222, and GORASP2_T225, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein insertion into ER membrane activity versus TOM1L2 in CCRCC (Pearson r = -0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	TOM1L2 →	-0.215	-0.025	.001	.008	3	4
HNSC	GORASP2_T222 →	+0.621	+0.073	<.001	.001	3	4
CCRCC	GORASP2_T225 →	+0.493	+0.027	.004	.009	2	5
CCRCC	HMOX2 →	+0.272	+0.020	<.001	.003	3	4
LUAD	MTMR3_S647 →	-0.236	-0.023	.005	.005	3	4
BRCA	APPL1 →	-0.253	-0.027	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045048 vs TOM1L2 — CCRCC

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