Protein insertion into ER membrane

Across TCGA patient cohorts, RNA activity of the Protein insertion into ER membrane pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYOCD, TCEAL7, and TRIM3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein insertion into ER membrane activity versus MYOCD in CCRCC (Pearson r = -0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	MYOCD →	-0.629	-0.220	.001	<.001	3	5
CCRCC	TCEAL7 →	-0.705	-0.170	.002	.003	3	5
COAD	TRIM3 →	-0.369	-0.193	.009	.001	3	4
LSCC	ARRB1 →	-0.444	-0.183	.003	.001	2	5
CCRCC	SHE →	-0.527	-0.156	<.001	<.001	3	4
LUAD	HMGN2P35 →	+0.367	+0.184	.002	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045048 vs MYOCD — CCRCC

Explore this scatter interactively →