Protein import into peroxisome membrane

Across TCGA patient cohorts, RNA activity of the Protein import into peroxisome membrane pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are COMT, MICAL3, and SNAP29, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein import into peroxisome membrane activity versus COMT in BRCA (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	COMT →	+0.434	+0.029	<.001	<.001	3	7
GBM	MICAL3 →	+0.346	+0.052	<.001	<.001	3	7
BRCA	SNAP29 →	+0.293	+0.037	<.001	<.001	3	6
GBM	BCL2L13 →	+0.318	+0.045	<.001	<.001	2	7
LSCC	CRKL →	+0.266	+0.051	<.001	<.001	3	6
GBM	ATXN10 →	+0.318	+0.026	<.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045046 vs COMT — BRCA

Explore this scatter interactively →