Protein import into peroxisome membrane

Across TCGA patient cohorts, RNA activity of the Protein import into peroxisome membrane pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EMP3, S100B, and CSDC2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein import into peroxisome membrane activity versus EMP3 in HNSC (Pearson r = -0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	EMP3 →	-0.575	-0.113	.001	.001	3	3
HNSC	S100B →	-0.597	-0.098	.008	.005	3	3
HNSC	CSDC2 →	-0.364	-0.149	.002	<.001	3	3
GBM	MEGF11 →	+0.569	+0.178	.006	.005	3	3
UCEC	OR2B6 →	+0.653	+0.610	<.001	<.001	3	3
UCEC	ACOX2 →	-0.519	-0.411	.003	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045046 vs EMP3 — HNSC

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