Protein import into peroxisome membrane

Across TCGA cell cohorts, RNA activity of the Protein import into peroxisome membrane pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLIT3, NDUFB11, and RPL41, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLIT3 grouped by Protein import into peroxisome membrane-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	SLIT3 →	-3.654	-1.671	.003	.002	3	4
URINARY_TRACT	NDUFB11 →	-0.566	-1.197	.009	.007	3	3
URINARY_TRACT	RPL41 →	+0.621	+1.381	<.001	<.001	3	3
BLOOD_Leukemia	FTSJ3 →	+0.654	+1.429	.003	<.001	3	3
SOFT_TISSUE	FGF5 →	+2.274	+1.299	.009	.003	3	3
PANCREAS	CIITA →	+0.751	+0.733	.007	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLIT3 by Protein import into peroxisome membrane activity — LIVER

Explore this box plot interactively →