Protein import into peroxisome membrane

Across TCGA cell cohorts, RNA activity of the Protein import into peroxisome membrane pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB8B, SLC2A3, and LARP6, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein import into peroxisome membrane activity versus RAB8B in KIDNEY (Pearson r = 0.83).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	RAB8B →	+2.716	+1.694	.004	<.001	3	11
LUNG_SCLC	SLC2A3 →	+1.987	+1.102	.002	.003	3	6
BLOOD_Leukemia	LARP6 →	+2.027	+1.069	<.001	<.001	3	5
LUNG_SCLC	BRI3BP →	-1.505	-1.174	<.001	<.001	3	5
CNS	ARHGAP29 →	+1.596	+0.721	.005	.004	3	5
BLOOD_Leukemia	S1PR1 →	+1.200	+0.835	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045046 vs RAB8B — KIDNEY

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