Protein insertion into mitochondrial inner membrane

Across TCGA cell cohorts, RNA activity of the Protein insertion into mitochondrial inner membrane pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are A4GALT, LGALS3BP, and MMP2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, A4GALT grouped by Protein insertion into mitochondrial inner membrane-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	A4GALT →	-2.285	-0.326	.007	.005	2	6
LUNG_NSCLC_LUAD	LGALS3BP →	-1.613	-0.158	.005	.001	2	6
STOMACH	MMP2 →	-3.188	-0.282	.007	<.001	3	5
STOMACH	CERCAM →	-3.626	-0.293	<.001	<.001	3	4
STOMACH	TPST1 →	-3.217	-0.315	<.001	<.001	3	4
SKIN	CDK8 →	+0.424	+0.279	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

A4GALT by Protein insertion into mitochondrial inner membrane activity — UPPER_AERODIGESTIVE_TRACT

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