Protein insertion into mitochondrial inner membrane

Across TCGA cell cohorts, RNA activity of the Protein insertion into mitochondrial inner membrane pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NENF, METRNL, and ATP6V0A2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein insertion into mitochondrial inner membrane activity versus NENF in LARGE_INTESTINE (Pearson r = -0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NENF →	-0.611	-0.216	<.001	.006	3	5
BLOOD_Myeloma	METRNL →	-2.287	-0.340	<.001	<.001	3	4
BLOOD_Myeloma	ATP6V0A2 →	+1.031	+0.281	.004	.006	3	4
LUNG_NSCLC_LUSC	RAB1A →	-1.004	-0.415	<.001	.002	3	4
LUNG_SCLC	PDS5B →	-0.883	-0.239	<.001	.001	3	4
SOFT_TISSUE	SLC31A2 →	-1.199	-0.361	.007	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045039 vs NENF — LARGE_INTESTINE

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