G0 to G1 transition

pathway activity — cross-omics
GO:0045023Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the G0 to G1 transition pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ISLR, LRRFIP1, and PSMB10_S230, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
CCRCCISLR →+0.459+0.023.009.00937
GBMLRRFIP1 →-0.370-0.067<.001<.00136
OVPSMB10_S230 →-0.966-0.044.002.00336
GBMSQOR →-0.547-0.052<.001<.00136
CCRCCDBN1 →+0.299+0.025.004.00227
GBMSDF2L1 →-0.357-0.064.001<.00136
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration