Actin nucleation

Across TCGA patient cohorts, RNA activity of the Actin nucleation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ABCA8, LMOD1, and KIF18B, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Actin nucleation activity versus ABCA8 in BRCA (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ABCA8 →	+0.625	+0.122	.003	.003	3	7
BRCA	LMOD1 →	+0.992	+0.187	<.001	<.001	3	7
GBM	KIF18B →	-0.927	-0.128	<.001	<.001	3	7
LUAD	CDCA3 →	-0.721	-0.117	<.001	<.001	3	6
HNSC	CENPF →	-1.161	-0.256	<.001	<.001	3	6
UCEC	KIF14 →	-1.041	-0.182	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045010 vs ABCA8 — BRCA

Explore this scatter interactively →