Actin nucleation

Across TCGA cell cohorts, RNA activity of the Actin nucleation pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PARP2, ATP6V1D, and BLZF1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PARP2 grouped by Actin nucleation-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	PARP2 →	+0.805	+0.953	.001	.009	2	4
BLOOD_Myeloma	ATP6V1D →	+1.731	+0.510	.001	<.001	3	3
BLOOD_Myeloma	BLZF1 →	+1.396	+0.451	<.001	<.001	3	3
BLOOD_Myeloma	DCAF4L1 →	+0.780	+0.464	.009	.001	3	3
BONE	SEPHS2 →	-0.481	-0.385	<.001	.009	3	3
OVARY	FCF1 →	+0.586	+0.925	<.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PARP2 by Actin nucleation activity — KIDNEY

Explore this box plot interactively →