Depyrimidination

Across TCGA patient cohorts, RNA activity of the Depyrimidination pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NEURL2, DSN1, and MIR6835, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Depyrimidination activity versus NEURL2 in UCEC (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NEURL2 →	+0.353	+0.880	.003	.008	3	4
UCEC	DSN1 →	+0.570	+0.798	<.001	<.001	3	4
BRCA	MIR6835 →	+0.784	+0.772	.002	.005	3	4
UCEC	POLA1 →	+0.295	+0.622	.005	.008	3	3
UCEC	LIG1 →	+0.595	+1.082	.003	.001	3	3
UCEC	CAV2 →	-0.522	-0.713	.005	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045008 vs NEURL2 — UCEC

Explore this scatter interactively →