DNA deamination

Across TCGA patient cohorts, RNA activity of the DNA deamination pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLSTN2, SERPING1, and CTLA4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DNA deamination activity versus CLSTN2 in BRCA (Pearson r = -0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CLSTN2 →	-1.557	-0.166	.001	<.001	3	5
UCEC	SERPING1 →	+0.814	+0.122	.002	.003	3	5
BRCA	CTLA4 →	+0.950	+0.203	<.001	<.001	3	5
BRCA	ZNF737 →	-0.735	-0.144	.002	.001	3	5
BRCA	APOBEC3C →	+0.971	+0.210	<.001	<.001	3	5
GBM	PTPN6 →	+0.637	+0.177	.003	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045006 vs CLSTN2 — BRCA

Explore this scatter interactively →