DNA deamination

Across TCGA cell cohorts, RNA activity of the DNA deamination pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RDH13, ANAPC5, and CDH3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RDH13 grouped by DNA deamination-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	RDH13 →	-0.922	-0.593	.004	.003	3	4
BONE	ANAPC5 →	-0.934	-1.646	.001	.001	3	4
BONE	CDH3 →	-1.483	-2.326	.001	<.001	3	4
CNS	SLC25A1 →	-0.870	-0.916	.002	.004	3	3
CNS	IGFBP2 →	-3.254	-0.822	.002	.005	2	4
LIVER	PRR5L →	-3.340	-2.237	<.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RDH13 by DNA deamination activity — OVARY

Explore this box plot interactively →