DNA deamination

Across TCGA cell cohorts, RNA activity of the DNA deamination pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMCC1, RNF19A, and TCOF1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DNA deamination activity versus TMCC1 in STOMACH (Pearson r = -0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	TMCC1 →	-0.813	-0.177	.001	.002	3	6
OVARY	RNF19A →	-1.298	-0.258	.001	<.001	3	4
BLOOD_Lymphoma	TCOF1 →	+0.788	+0.194	.005	.009	3	4
BREAST	KLF8 →	-1.769	-0.761	<.001	.004	3	3
BREAST	CDC20 →	+1.132	+0.984	.002	.004	3	3
BREAST	KIF14 →	+0.785	+0.768	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045006 vs TMCC1 — STOMACH

Explore this scatter interactively →