DNA-templated DNA replication maintenance of fidelity

Across TCGA patient cohorts, RNA activity of the DNA-templated DNA replication maintenance of fidelity pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NUF2, EXO1, and ASPM, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DNA-templated DNA replication maintenance of fidelity activity versus NUF2 in BRCA (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NUF2 →	+0.893	+0.772	.001	.001	3	6
GBM	EXO1 →	+0.657	+0.555	.001	.002	3	6
GBM	ASPM →	+1.407	+0.875	<.001	.001	3	6
LSCC	WDR62 →	+0.890	+0.545	<.001	<.001	3	6
COAD	LILRA1 →	-0.413	-0.617	<.001	.004	3	5
OV	DSE →	-0.409	-0.562	.007	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045005 vs NUF2 — BRCA

Explore this scatter interactively →