DNA-templated DNA replication maintenance of fidelity

Across TCGA cell cohorts, RNA activity of the DNA-templated DNA replication maintenance of fidelity pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GBP1, APOL3, and PIAS2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, DNA-templated DNA replication maintenance of fidelity activity versus GBP1 in BLOOD_Leukemia (Pearson r = -0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GBP1 →	-1.846	-0.121	.001	.008	3	4
BLOOD_Leukemia	APOL3 →	-2.507	-0.194	<.001	.001	3	4
SKIN	PIAS2 →	+0.782	+0.190	.001	.003	3	4
BONE	HSPE1 →	-1.004	-0.163	<.001	.002	3	4
UPPER_AERODIGESTIVE_TRACT	RAB11A →	+0.552	+0.184	.007	.006	2	4
CNS	CD52 →	-0.750	-0.176	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045005 vs GBP1 — BLOOD_Leukemia

Explore this scatter interactively →