Double-strand break repair via synthesis-dependent strand annealing

Across TCGA cell cohorts, RNA activity of the Double-strand break repair via synthesis-dependent strand annealing pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAD51, KDM5B, and RAD52, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAD51 grouped by Double-strand break repair via synthesis-dependent strand annealing-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	RAD51 →	-0.655	-0.350	<.001	<.001	3	9
OVARY	KDM5B →	+0.136	+0.167	.001	.003	3	4
BREAST	RAD52 →	-0.262	-0.163	.006	.001	3	4
LUNG_NSCLC_LUSC	MST1R →	+0.109	+0.185	.008	.009	3	4
STOMACH	GABPB2 →	+0.389	+0.175	.003	.002	2	5
SOFT_TISSUE	NRCAM →	+0.244	+0.371	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAD51 by Double-strand break repair via synthesis-dependent strand annealing activity — SOFT_TISSUE

Explore this box plot interactively →