Double-strand break repair via synthesis-dependent strand annealing

Across TCGA cell cohorts, RNA activity of the Double-strand break repair via synthesis-dependent strand annealing pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CTC1, TCF3, and CBLN3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CTC1 grouped by Double-strand break repair via synthesis-dependent strand annealing-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CTC1 →	+0.816	+0.237	.002	.002	2	6
LUNG_NSCLC_LUAD	TCF3 →	+0.982	+0.188	<.001	<.001	3	4
BLOOD_Myeloma	CBLN3 →	+1.484	+0.244	.001	<.001	3	4
SOFT_TISSUE	GDPD1 →	+1.478	+0.355	.005	.003	3	4
SOFT_TISSUE	PLA2G6 →	+1.055	+0.310	.008	.007	3	4
LUNG_SCLC	MX1 →	-2.325	-0.281	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CTC1 by Double-strand break repair via synthesis-dependent strand annealing activity — BREAST

Explore this box plot interactively →