Double-strand break repair via synthesis-dependent strand annealing

Across TCGA cell cohorts, RNA activity of the Double-strand break repair via synthesis-dependent strand annealing pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZRANB1, TMEFF1, and SNX5, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Double-strand break repair via synthesis-dependent strand annealing activity versus ZRANB1 in BLOOD_Leukemia (Pearson r = 0.80).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ZRANB1 →	+1.282	+1.306	.004	<.001	3	2
BLOOD_Leukemia	TMEFF1 →	+1.498	+1.293	.001	<.001	3	2
BLOOD_Leukemia	SNX5 →	+0.782	+1.285	.004	.002	3	2
BLOOD_Leukemia	DDX24 →	+0.828	+1.220	.008	.002	3	2
BLOOD_Leukemia	DHPS →	+0.700	+1.235	<.001	.002	3	2
BLOOD_Lymphoma	TTI1 →	+0.934	+1.063	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045003 vs ZRANB1 — BLOOD_Leukemia

Explore this scatter interactively →