Double-strand break repair via single-strand annealing

Across TCGA patient cohorts, RNA activity of the Double-strand break repair via single-strand annealing pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TRNT1, TAF10, and TOP2B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Double-strand break repair via single-strand annealing activity versus TRNT1 in OV (Pearson r = 0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TRNT1 →	+0.236	+0.023	.002	.003	3	6
LSCC	TAF10 →	+0.185	+0.042	.002	.005	3	5
HNSC	TOP2B →	+0.373	+0.062	<.001	<.001	3	5
BRCA	EGFR →	-0.597	-0.030	.001	.004	3	5
LSCC	ITGB4 →	-0.482	-0.031	.001	.009	3	5
GBM	KIAA1143 →	+0.342	+0.048	.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0045002 vs TRNT1 — OV

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