Double-strand break repair via single-strand annealing

Across TCGA cell cohorts, RNA activity of the Double-strand break repair via single-strand annealing pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAD52, RBBP8, and SLX4, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAD52 grouped by Double-strand break repair via single-strand annealing-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RAD52 →	-0.449	-0.449	<.001	.002	3	10
LUNG_NSCLC_LUSC	RBBP8 →	-0.287	-0.295	.004	.003	3	6
BREAST	SLX4 →	-0.124	-0.600	.004	.006	3	4
CNS	OGG1 →	-0.224	-1.067	.009	<.001	2	4
CNS	LSM1 →	+0.170	+0.652	.006	.002	3	3
LIVER	HTR7 →	+0.210	+0.303	.007	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAD52 by Double-strand break repair via single-strand annealing activity — LARGE_INTESTINE

Explore this box plot interactively →