Lipoprotein localization

Across TCGA patient cohorts, RNA activity of the Lipoprotein localization pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYO1F, IL16, and MEIS2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lipoprotein localization activity versus MYO1F in LSCC (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MYO1F →	+0.614	+0.243	<.001	<.001	3	5
LSCC	IL16 →	+0.715	+0.276	<.001	<.001	3	5
UCEC	MEIS2 →	-0.699	-0.264	.009	.005	3	5
CCRCC	SEC24D →	+0.569	+0.254	<.001	<.001	3	5
LUAD	FOLR2 →	+0.626	+0.204	.001	.004	3	5
LUAD	GPR34 →	+0.459	+0.203	.003	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044872 vs MYO1F — LSCC

Explore this scatter interactively →