Lipoprotein localization

Across TCGA cell cohorts, RNA activity of the Lipoprotein localization pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GRIN1, NOMO3, and RAD50, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GRIN1 grouped by Lipoprotein localization-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	GRIN1 →	-0.517	-0.256	.006	.001	3	4
LARGE_INTESTINE	NOMO3 →	-1.276	-1.229	<.001	<.001	3	4
LARGE_INTESTINE	RAD50 →	-0.771	-0.702	.001	.001	3	4
OESOPHAGUS	MTM1 →	-0.880	-0.690	.001	.009	2	5
STOMACH	YARS1 →	+0.596	+0.899	.004	.007	3	4
SOFT_TISSUE	IFNGR2 →	+0.648	+0.970	.003	.006	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GRIN1 by Lipoprotein localization activity — URINARY_TRACT

Explore this box plot interactively →