Lipoprotein localization

Across TCGA cell cohorts, RNA activity of the Lipoprotein localization pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MSANTD3, C3orf18, and MUC1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lipoprotein localization activity versus MSANTD3 in OVARY (Pearson r = -0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	MSANTD3 →	-0.861	-1.419	.001	<.001	3	5
LUNG_NSCLC_LUAD	C3orf18 →	-1.107	-0.950	<.001	.001	3	5
BLOOD_Leukemia	MUC1 →	+1.469	+0.667	<.001	.008	3	5
URINARY_TRACT	YIPF2 →	+1.002	+1.602	.004	.004	3	5
STOMACH	PALD1 →	-2.161	-1.345	.008	.006	3	5
LARGE_INTESTINE	CCDC34 →	-0.462	-1.117	.007	<.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0044872 vs MSANTD3 — OVARY

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